Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Beta (β) cell dysfunction or loss is the common pathological feature in all types of diabetes
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …

Endocrine pancreatic β cells require endothelial signals for their differentiation and function.
However, the molecular basis for such signals remains unknown. Here, we show that β cells …

The appearance of multicellular organisms imposed the development of several
mechanisms for cell-to-cell communication, whereby different types of cells coordinate their …

Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

Background The function and viability of cultured, transplanted, or encapsulated pancreatic
islets is often limited by hypoxia because these islets have lost their vasculature during the …

The islets of Langerhans consist of endocrine cells embedded in a network of specialized
capillaries that regulate islet blood flow. Despite evidence for a critical role of islet perfusion …

Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …

Taken together the Islets of Langerhans form a nutrient sensing network spread throughout
the pancreas. They are tightly connected to the source organ-the intestine-and the target …

Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …