Modeling psychotic disorders: Environment x environment interaction

K Murlanova, MV Pletnikov - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …

[HTML][HTML] Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations

S Kilpatrick, C Irwin, KK Singh - Translational Psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder caused by
genetic or environmental perturbations during early development. Diagnoses are dependent …

[HTML][HTML] Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable

K Sarieva, T Kagermeier, S Khakipoor, E Atay… - Molecular …, 2023 - nature.com
Maternal immune activation (MIA) during critical windows of gestation is correlated with long-
term neurodevelopmental deficits in the offspring, including increased risk for autism …

[HTML][HTML] Preservation of co-expression defines the primary tissue fidelity of human neural organoids

JM Werner, J Gillis - bioRxiv, 2023 - ncbi.nlm.nih.gov
Human neural organoid models offer an exciting opportunity for studying often inaccessible
human-specific brain development; however, it remains unclear how precisely organoids …

Systematic comparison of basic animal models of cerebral hypoperfusion

V Chrishtop, V Nikonorova, A Gutsalova… - Tissue and Cell, 2022 - Elsevier
Various surgical interventions into the head and neck vasculature differentially impact
nature, localization and dynamics of ischemic changes in the brain structures. In this regard …

[HTML][HTML] Aging phenotype in AD brain organoids: Track to success and challenges

MK Hossain, HR Kim, HJ Chae - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation
in the brain causing memory loss and cognitive decline. Traditional models fall short in AD …

[HTML][HTML] Disruption of the gene regulatory programme in neurodevelopmental disorders

A Griffin, A Mahesh, VK Tiwari - Biochimica et Biophysica Acta (BBA)-Gene …, 2022 - Elsevier
Cortical development consists of a series of synchronised events, including fate transition of
cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear …

[HTML][HTML] Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?

P Marrazzo, M Cricca, C Nastasi - Pathogens, 2021 - mdpi.com
In order to prevent new pathogen outbreaks and avoid possible new global health threats, it
is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents …

[HTML][HTML] Roadbumps at the Crossroads of Integrating Behavioral and In Vitro Approaches for Neurotoxicity Assessment

GJ Harry, S Mcbride, SK Witchey… - Frontiers in …, 2022 - frontiersin.org
With the appreciation that behavior represents the integration and complexity of the nervous
system, neurobehavioral phenotyping and assessment has seen a renaissance over the last …

Prenatal hypoxia affects nicotine consumption and withdrawal in adult rats via impairment of the glutamate system in the brain

VA Stratilov, OV Vetrovoy, EI Tyulkova - Molecular Neurobiology, 2022 - Springer
The role of damaging factors in the prenatal period as a basis for drug addiction in offspring
is of great interest. In this study, we aim at deciphering the effects and possible mechanisms …