The fragmentation of oligonucleotides by mass spectrometry allows for the determination of
their sequences. It is necessary to understand how oligonucleotides dissociate in the gas …

The first oligonucleotide therapeutic was approved by the Food and Drug Administration in
1998, and since then, 12 nucleic acids have been commercialised as medicines. To be …

Ion mobility spectrometers (IMS) are able to detect ppt V-level concentrations of substances
in gasses and in liquids within seconds. Due to the continuous increase in analytical …

The ability to use positive ion monitoring mode with an atmospheric pressure ion mobility
time-of-flight mass spectrometer (APIM (tof) MS) to detect psychoactive cathinones and …

Nucleic acid modifications play important roles in biological activities and disease
occurrences, and have been considered as cancer biomarkers. Due to the relatively low …

Ion mobility spectrometry coupled to multi capillary columns (MCC/IMS) combines highly
sensitive spectrometry with a rapid separation technique. MCC\IMS is widely used for …

Ion mobility coupling to mass spectrometry facilitates enhanced identification certitude.
Further coupling to liquid chromatography results in multi-dimensional analytical methods …

A novel method based on hollow fibre liquid phase microextraction coupled with a hand-
held ion mobility spectrometer was developed for determination of seven pesticides in …

A computational fluid dynamics-Monte Carlo approach (abbreviated as CMC) based on
SIMION has been developed for simulating the ions trajectories in both the fluid and electric …

An approach using method validation (MV) parameters, otherwise known as analytical
figures of merit was combined with electrospray ionization high performance ion mobility …