Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …

Highlights•Novel articular cartilage tissue engineering therapies have been
developed.•Integration of engineered tissue with native cartilage is an ongoing …

Mesenchymal stem cells (MSCs) are located in various tissues where these cells show
niche‐dependent multilineage differentiation and secrete immunomodulatory molecules to …

Mesenchymal stem cells (MSCs) represent the most clinically used stem cells in
regenerative medicine. However, due to the disadvantages with primary MSCs, such as …

The burden of musculoskeletal disorders (MSK) is increasing worldwide. It affects millions of
people worldwide, decreases their quality of life, and can cause mortality. The treatment of …

Background Articular cartilage degeneration can result from injury, age, or arthritis, causing
significant joint pain and disability without surgical intervention. Currently, the only FDA cell …

Histone methylation status is an important process associated with cell growth, survival,
differentiation and gene expression in human diseases. As a member of the KDM4 family …

The past decade has seen a proliferation of drugs that target epigenetic pathways. Many of
these drugs were developed to treat acute myeloid leukemia, a condition in which …

Scar formation during normal tissue regeneration in adults may result in noticeable cosmetic
and functional defects and have a significant impact on the quality of life. In contrast, fetal …

Background The pumping function of corneal endothelial cells (CECs) plays a pivotal role in
the maintenance of corneal water homeostasis. Corneal endothelial dysfunction (CED) …