Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Effective crop protection is vital to safeguard food security, but growers are reliant on a
limited toolbox in the face of diverse and evolving pathogens. New crop protection methods …

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …

Climate change imposes a severe threat to agricultural systems, food security, and human
nutrition. Meanwhile, efforts in crop and livestock gene editing have been undertaken to …

Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …

Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …

Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …

If they are able to spread in wild populations, CRISPR-based gene-drive elements would
provide new ways to address ecological problems by altering the traits of wild organisms …

There is an increasing demand for evolutionary models to incorporate relatively realistic
dynamics, ranging from selection at many genomic sites to complex demography …

CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to
mosquito control. While attempts have been made to develop such systems in Aedes …