Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These
capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses …

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …

The order Herpesvirales contains viruses infecting animals from molluscs to men with a
common virion morphology which have been classified into the families Herpesviridae …

Virus infection has been one of the main causes of human death since the ancient times.
Even though more and more antiviral drugs have been approved in clinic, long-term use can …

The herpes simplex virus type 1 (HSV-1) genome is contained in a capsid wrapped by a
complex tegument layer and an external envelope. The poorly defined tegument plays a …

Herpes virions are amongst the most complex virus particles: they comprise in excess of
thirty virally encoded proteins, and also contain cellular components. Capsid formation and …

Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …

Many viruses depend on host microtubule motors to reach their destined intracellular
location. Viral particles of neurotropic alphaherpesviruses such as herpes simplex virus 1 …

Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …