Identifying key players and their interactions is fundamental for understanding biochemical
mechanisms at the molecular level. The ever-increasing number of alternative ways to …

Protein interactions are a fundamental mechanism for the generation of biological regulatory
specificity. The study of protein interactions in living cells is of particular significance …

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …

The prosurvival BCL2 family member MCL1 is frequently dysregulated in cancer. To
overcome the significant challenges associated with inhibition of MCL1 protein–protein …

LY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and
occupies both protomers in RAF dimers. Biochemical and cellular analyses revealed that …

▪ Abstract To advance our understanding of biological processes as they occur in living
animals, imaging strategies have been developed and refined that reveal cellular and …

▪ Abstract Expressed protein ligation (EPL) is a protein engineering approach that allows
recombinant and synthetic polypeptides to be chemoselectively and regioselectively joined …

APEX is an engineered peroxidase that catalyzes the oxidation of a wide range of
substrates, facilitating its use in a variety of applications from subcellular staining for electron …

In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to
the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a …

Signaling pathways regulating proliferation, differentiation, and apoptosis are commonly
mediated through protein–protein interactions as well as reversible phosphorylation of …