RNA splicing regulators play critical roles in neurogenesis
Alternative RNA splicing increases transcript diversity in different cell types and under
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …
[HTML][HTML] A large-scale binding and functional map of human RNA-binding proteins
EL Van Nostrand, P Freese, GA Pratt, X Wang, X Wei… - Nature, 2020 - nature.com
Many proteins regulate the expression of genes by binding to specific regions encoded in
the genome 1. Here we introduce a new data set of RNA elements in the human genome …
the genome 1. Here we introduce a new data set of RNA elements in the human genome …
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling
R Micheletti, I Plaisance, BJ Abraham, A Sarre… - Science translational …, 2017 - science.org
Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac
development and disease. However, our understanding of the importance of these …
development and disease. However, our understanding of the importance of these …
Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study
S Ambatipudi, C Cuenin, H Hernandez-Vargas… - …, 2016 - Taylor & Francis
Aim: Epigenetic changes may occur in response to environmental stressors, and an altered
epigenome pattern may represent a stable signature of environmental exposure. Materials & …
epigenome pattern may represent a stable signature of environmental exposure. Materials & …
PTBP3-mediated regulation of ZEB1 mRNA stability promotes epithelial–mesenchymal transition in breast cancer
The RNA polypyrimidine tract-binding protein PTBP3 is a little studied paralog of PTBP1,
which has oncogenic properties. In this study, we demonstrate that PTBP3 induces epithelial …
which has oncogenic properties. In this study, we demonstrate that PTBP3 induces epithelial …
LncRNA Meg3 protects endothelial function by regulating the DNA damage response
MS Shihabudeen Haider Ali, X Cheng… - Nucleic acids …, 2019 - academic.oup.com
The role of long non-coding RNAs (lncRNAs) in regulating endothelial function through the
DNA damage response (DDR) remains poorly understood. In this study, we demonstrate …
DNA damage response (DDR) remains poorly understood. In this study, we demonstrate …
Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor
Many unannotated microproteins and alternative proteins (alt-proteins) are coencoded with
canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt …
canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt …
Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein
(hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the …
(hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the …
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers
E Monzón-Casanova, M Screen, MD Díaz-Muñoz… - Nature …, 2018 - nature.com
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between
the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with …
the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with …
RETRACTED ARTICLE: PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612
X Yang, S Qu, L Wang, H Zhang, Z Yang, J Wang… - Oncogene, 2018 - nature.com
Nuclear-enriched RNA-binding proteins (RBPs) are mainly involved in transcriptional
regulation, which is a critical checkpoint to tune gene diversity and expression levels. We …
regulation, which is a critical checkpoint to tune gene diversity and expression levels. We …