Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

PD Lu, YH Zhao - Chinese medicine, 2020 - Springer
Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor
involved in regulating gene transcription to influence pathological evolution of inflammatory …

[HTML][HTML] Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review

GR Gandhi, T Mohana, K Athesh, VE Hillary… - Journal of …, 2023 - Elsevier
This review aims to identify in vivo studies investigating the potential of plant substances and
their natural molecules in managing inflammatory bowel disease (IBD). Specifically, the …

Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota …

C Li, G Ai, Y Wang, Q Lu, C Luo, L Tan, G Lin… - Pharmacological …, 2020 - Elsevier
Abstract Berberine (BBR), a naturally-occurring isoquinoline alkaloid isolated from several
Chinese herbal medicines, has been widely used for the treatment of dysentery and colitis …

Gut microbiota modulation and anti-inflammatory properties of mixed lactobacilli in dextran sodium sulfate-induced colitis in mice

J Shi, Q Xie, Y Yue, Q Chen, L Zhao, SE Evivie, B Li… - Food & Function, 2021 - pubs.rsc.org
Correlations between gut microbiota activities and inflammatory bowel disease (IBD)
treatment are gaining research interest. In our previous study, Lactobacillus acidophilus …

Canna x generalis LH Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress …

TN Mahmoud, WH El-Maadawy, ZA Kandil… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Genus Canna is used in folk medicine as
demulcent, diaphoretic, antipyretic, mild laxative and in gastrointestinal upsets therapy …

Indigenous uses, phytochemical analysis, and anti-inflammatory properties of Australian tropical medicinal plants

K Yeshi, G Turpin, T Jamtsho, P Wangchuk - Molecules, 2022 - mdpi.com
Australian tropical plants have been a rich source of food (bush food) and medicine to the
first Australians (Aboriginal people), who are believed to have lived for more than 50,000 …

COX-2–PGE2 signaling impairs intestinal epithelial regeneration and associates with TNF inhibitor responsiveness in ulcerative colitis

Y Li, C Soendergaard, FH Bergenheim, DM Aronoff… - …, 2018 - thelancet.com
Background Inhibition of tumor necrosis factor-α (TNF) signaling is beneficial in the
management of ulcerative colitis (UC), but up to one-third of patients do not have a clinical …

Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice

C Li, N Dong, B Wu, Z Mo, J Xie, Q Lu - Phytomedicine, 2021 - Elsevier
Background As a chronic inflammatory disease, ulcerative colitis (UC) is relevant to a rising
risk of colorectal cancer. Dihydroberberine (DHBB), a natural occurring isoquinoline alkaloid …

Inflammasome-targeting natural compounds in inflammatory bowel disease: Mechanisms and therapeutic potential

Q Xu, W Sun, J Zhang, Y Mei, J Bao, S Hou… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), mainly including Crohn's disease and ulcerative colitis,
seriously affects human health and causes substantial social and economic burden. The …

Study of the therapeutic effect of raw and processed Vladimiriae Radix on ulcerative colitis based on intestinal flora, metabolomics and tissue distribution analysis

ZW Yu, Y Xie, ZC Huang, K Yang, ZG Wang, HL Hu - Phytomedicine, 2021 - Elsevier
Background The intestinal flora imbalance and metabolic disorders are closely related to the
pathogenesis of ulcerative colitis (UC). As a commonly used herb for the treatment of …