Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …

Objective The objective is to formulate clinical practice guidelines for the treatment of
diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more …

More than 25% of the US population aged $65 years has diabetes (1), and the aging of the
overall population is a significant driver of the diabetes epidemic. Although the burden of …

Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional
foods, this comprehensive and timely book presents an abundance of information on herbal …

According to the most recent surveillance data, the prevalence of diabetes among US adults
over age 65 years varies from 22% to 33%, depending on the diagnostic criteria employed …

Islets of Langerhans are fundamental in understanding diabetes. A healthy human pancreas
from a donor has been used to asses various islet parameters and their three-dimensional …

Ageing is a process characterized by a progressive decline in cellular function, organismal
fitness and increased risk of age-related diseases and death. Several hundred theories …

OBJECTIVE Regeneration of the insulin-secreting β-cells is a fundamental research goal
that could benefit patients with either type 1 or type 2 diabetes. β-Cell proliferation can be …

OBJECTIVE—Type 2 diabetes is characterized by impaired insulin secretion in response to
increased metabolic demand. This defect in β-cell compensation seems to result from the …