Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

B Zingales, MA Miles, DA Campbell… - Infection, genetics and …, 2012 - Elsevier
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Trypanosoma cruzi and Chagas' disease in the United States

C Bern, S Kjos, MJ Yabsley… - Clinical microbiology …, 2011 - Am Soc Microbiol
Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi and causes
potentially life-threatening disease of the heart and gastrointestinal tract. The southern half …

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

NM El-Sayed, PJ Myler, DC Bartholomeu, D Nilsson… - Science, 2005 - science.org
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the
diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 …

Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human–host interactions

LMD Magalhães, KJ Gollob, B Zingales… - The Lancet …, 2022 - thelancet.com
The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Vetores da doença de Chagas no Brasil

C Galvão - 2014 - books.scielo.org
Os triatomíneos são insetos hematófagos de grande importância médica, pois são os
responsáveis pela transmissão do Trypanosoma cruzi, o agente etiológico da doença de …

[HTML][HTML] Trypanosoma cruzi: adaptation to its vectors and its hosts

F Noireau, P Diosque, AM Jansen - Veterinary research, 2009 - ncbi.nlm.nih.gov
American trypanosomiasis is a parasitic zoonosis that occurs throughout Latin America. The
etiological agent, Trypanosoma cruzi, is able to infect almost all tissues of its mammalian …

Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease

AM Macedo, CR Machado, RP Oliveira… - Memorias do Instituto …, 2004 - SciELO Brasil
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical
course, ranging from symptomless infection to severe chronic disease with cardiovascular or …

Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids

M Yeo, N Acosta, M Llewellyn, H Sánchez… - International journal for …, 2005 - Elsevier
Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal
intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five …