Tissue regulatory T cells: regulatory chameleons
AR Muñoz-Rojas, D Mathis - Nature Reviews Immunology, 2021 - nature.com
Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
Epithelial cell–derived cytokines: more than just signaling the alarm
F Roan, K Obata-Ninomiya… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …
are central regulators of type 2 immunity, which drives a broad array of allergic responses …
Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics
MAC Depuydt, KHM Prange, L Slenders, T Örd… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …
molecular complexity within the cells of human plaques has not been fully assessed …
Single-cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation
Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely
unexplored phenotype and development. We used single-cell RNA-seq to characterize …
unexplored phenotype and development. We used single-cell RNA-seq to characterize …
Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
Interleukin-2 and regulatory T cells in rheumatic diseases
Failure of regulatory T (Treg) cells to properly control immune responses leads invariably to
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis
E Jou, N Rodriguez-Rodriguez, ACF Ferreira… - Science …, 2022 - science.org
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against
intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33 …
intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33 …
Regulatory T cells: the many faces of Foxp3
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …
requisite role in the maintenance of immunological homeostasis and prevention of …
Type 2 immunity: Expanding our view
CM Lloyd, RJ Snelgrove - Science immunology, 2018 - science.org
The classical vision of type 2 immune reactions is that they are characterized by a distinct
cellular and cytokine repertoire that is critical for host resistance against helminthic worm …
cellular and cytokine repertoire that is critical for host resistance against helminthic worm …
Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche
Maintenance of tissue homeostasis is dependent on the communication between stem cells
and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a …
and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a …