Playing With Fire: Proinflammatory Virulence Mechanisms of Group A Streptococcus
Group A Streptococcus is an obligate human pathogen that is a major cause of infectious
morbidity and mortality. It has a natural tropism for the oropharynx and skin, where it causes …
morbidity and mortality. It has a natural tropism for the oropharynx and skin, where it causes …
Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection
Group A streptococcus (GAS) infection may cause severe life-threatening diseases,
including necrotizing fasciitis and streptococcal toxic shock syndrome. Despite the …
including necrotizing fasciitis and streptococcal toxic shock syndrome. Despite the …
Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice
PP Yang, GC Yeh, EYK Huang, PY Law… - Journal of Biomedical …, 2015 - Springer
Background Neuropathic pain is a very troublesome and difficult pain to treat. Although
opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among …
opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among …
Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics – implications for pathogenesis
S treptococcus pyogenes (group A streptococcus, GAS) secretes streptokinase, a potent
plasminogen activating protein. Among GAS isolates, streptokinase gene sequences (ska) …
plasminogen activating protein. Among GAS isolates, streptokinase gene sequences (ska) …
Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes …
N Tsao, CF Kuo, MH Cheng, WC Lin, CF Lin, YS Lin - Scientific reports, 2019 - nature.com
Abstract Group A Streptococcus (GAS) infection is associated with a variety of human
diseases. Previous studies indicate GAS infection leads to RAW264. 7 cell death, but the …
diseases. Previous studies indicate GAS infection leads to RAW264. 7 cell death, but the …
Regulation of the mammalian SWI/SNF family of chromatin remodeling enzymes by phosphorylation during myogenesis
T Padilla-Benavides, P Reyes-Gutierrez, AN Imbalzano - Biology, 2020 - mdpi.com
Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of
myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms …
myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms …
Dextromethorphan analgesia in a human experimental model of hyperalgesia.
E Martin, C Narjoz, X Decleves, L Labat, C Lambert… - …, 2019 - europepmc.org
Background Central pain sensitization is often refractory to drug treatment.
Dextromethorphan, an N-methyl-D-aspartate receptor antagonist, is antihyperalgesic in …
Dextromethorphan, an N-methyl-D-aspartate receptor antagonist, is antihyperalgesic in …
A mouse air pouch model for evaluating the anti-bacterial efficacy of phage MR-5 in resolving skin and soft tissue infection induced by methicillin-resistant …
S Kaur, S Chhibber - Folia Microbiologica, 2021 - Springer
With the alarming rise in antimicrobial resistance, phage therapy represents a new paradigm
for combating antibiotic-resistant infectious diseases that is worth exploring for its clinical …
for combating antibiotic-resistant infectious diseases that is worth exploring for its clinical …
Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment
Recent studies show that proinflammatory cytokines might be related to the development of
opioid dependence (physiological, psychological, or both). In a double-blind, randomly …
opioid dependence (physiological, psychological, or both). In a double-blind, randomly …
Dextromethorphan inhibits activations and functions in dendritic cells
DY Chen, PS Song, JS Hong, CL Chu… - Journal of …, 2013 - Wiley Online Library
Dendritic cells (DCs) play an important role in connecting innate and adaptive immunity.
Thus, DCs have been regarded as a major target for the development of immunomodulators …
Thus, DCs have been regarded as a major target for the development of immunomodulators …