Thyrotoxic effects of mixed exposure to perfluorinated compounds: Integrating population-based, toxicogenomic, animal, and cellular evidence to elucidate molecular …
X Du, X Xu, H Yu, Z Du, Y Wu, K Qian… - Environmental …, 2024 - ACS Publications
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging environmental
endocrine disruptors that may adversely affect the human endocrine system, particularly the …
endocrine disruptors that may adversely affect the human endocrine system, particularly the …
[HTML][HTML] Development of chemical categories for per-and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential …
Per-and Polyfluoroalkyl substances (PFAS) are a class of manufactured chemicals that are
in widespread use and many present concerns for persistence, bioaccumulation and toxicity …
in widespread use and many present concerns for persistence, bioaccumulation and toxicity …
Screening the ToxCast Chemical Libraries for Binding to Transthyretin
SA Eytcheson, AD Zosel, JH Olker… - Chemical Research …, 2024 - ACS Publications
Transthyretin (TTR) is one of the serum binding proteins responsible for transport of thyroid
hormones (TH) to target tissue and for maintaining the balance of available TH. Chemical …
hormones (TH) to target tissue and for maintaining the balance of available TH. Chemical …
[HTML][HTML] In Vitro Hepatic Clearance Evaluations of Per-and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories
DM Crizer, JR Rice, MG Smeltz, KS Lavrich… - Toxics, 2024 - mdpi.com
Toxicokinetic (TK) assays and in vitro–in vivo extrapolation (IVIVE) models are New
Approach Methods (NAMs) used to translate in vitro points of departure to exposure …
Approach Methods (NAMs) used to translate in vitro points of departure to exposure …
[HTML][HTML] Per-and Polyfluoroalkyl Substances (PFAS) as Emerging Obesogens: Mechanisms, Epidemiological Evidence, and Regulatory Challenges
The pervasive presence of per-and polyfluoroalkyl substances (PFAS) in the environment
and their persistent nature raise significant concerns regarding their impact on human …
and their persistent nature raise significant concerns regarding their impact on human …
[HTML][HTML] Using zebrafish to screen developmental toxicity of per-and polyfluoroalkyl substances (PFAS)
KN Britton, RS Judson, BN Hill, KA Jarema, JK Olin… - Toxics, 2024 - mdpi.com
Per-and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial
products. While some PFAS, notably perfluorooctanoic acid (PFOA) and …
products. While some PFAS, notably perfluorooctanoic acid (PFOA) and …
[HTML][HTML] Serum metabolome associated with novel and legacy per-and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated …
F Wang, Y Lin, L Qin, X Zeng, H Jiang, Y Liang… - Environment …, 2024 - Elsevier
Background Exposure to per-and polyfluoroalkyl substances (PFAS) may linked to thyroid
cancer (TC) risk, but inconsistent findings and a lack of studies on mixed exposures exist …
cancer (TC) risk, but inconsistent findings and a lack of studies on mixed exposures exist …
Exploring the neurotoxicity of chiral dinotefuran towards nicotinic acetylcholine receptors: Enantioselective insights into species selectivity
ZC He, T Zhang, W Peng, Q Mei, QZ Wang… - Journal of Hazardous …, 2024 - Elsevier
Dinotefuran is a chiral neonicotinoid that is widely distributed in environmental matrices, but
its health risks to different organisms are poorly understood. This study investigated the …
its health risks to different organisms are poorly understood. This study investigated the …
In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin
SA Eytcheson, AD Zosel, JH Olker… - Chemical Research …, 2024 - ACS Publications
Thyroid hormone (TH) carrier proteins play an important role in distributing TH to target
tissue as well as maintaining the balance of free versus bound TH in the blood. Interference …
tissue as well as maintaining the balance of free versus bound TH in the blood. Interference …
Association between per-and polyfluoroalkyl substance exposures and thyroid homeostasis parameters
X Yu, Y Liu, M Wang, P Jia, S Yang… - The Journal of …, 2024 - academic.oup.com
Context Prevailing studies have shown the disruption effect of per-and polyfluoroalkyl
substances (PFAS) on thyroid homeostasis. However, most studies have focused on …
substances (PFAS) on thyroid homeostasis. However, most studies have focused on …