Donor–recipient matching is a highly individualized and complex component of solid organ
transplantation. Flowcytometry crossmatching (FC-XM) is an integral step in the matching …

Flow cytometry crossmatching (FC‐XM) assay is the most sensitive cell‐based method for
detecting donor‐specific antibodies (DSAs). However, the use of FC‐XM remains limited by …

The serological complement-dependent cytotoxicity crossmatch (CDC-XM) permits routine
identification of anti-donor alloantibodies in the sera of allotransplant recipients. However, in …

The presence of preformed donor-specific HLA antibodies leads to early antibody mediated
kidney allograft rejection. Therefore, detection and avoidance of donor reactive HLA …

Background Complement-dependent lymphocytotoxicity (CDC-XM) and flow-cytometric
(FCXM) cross-match are analyzed individually for each donor and recipient pair, because …

In this study we have evaluated an alternative 96‐well format flow cytometry based (FCtox)
method which enable simultaneous detection of cytotoxicity and human leukocyte antigen …

Anti-HLA-specific donor antibodies induce rapid, irreversible destruction of the transplant
(hyperacute rejection) that today happens rarely due to immunologic studies—prospective …

Cytotoxic flow cytometric crossmatch (cFCXM), identified by detecting complement-mediated
cytotoxic cell death in addition to the capability of showing the alloantibodies binding onto …

The donor/recipient matching in kidney transplantation is based on approved laboratory
tests, which are complement-dependent cytotoxic crossmatch (CDC-XM) and flow cytometry …

Background C1q-binding donor-specific antibody (DSA) is detrimental to transplanted
kidney function. However, the factors that affect C1q binding status are unclear. Methods A …