Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Simple Summary The gastrointestinal tract is a complex organization of various types of
epithelial cells forming a single layer of the mucosal barrier, the host mucosal immune …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Paneth cells are the primary source of C-type lysozyme, a β-1, 4-N-
acetylmuramoylhydrolase that enzymatically processes bacterial cell walls. Paneth cells are …

Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC
compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but …

Damage to the intestinal stem cell niche can result from mechanical stress, infections,
chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to …

The intestinal epithelium is a rapidly renewing cellular compartment. This constant
regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance …

IBD syndromes such as Crohn's disease and ulcerative colitis result from the inflammation of
specific intestinal segments. Although many studies have reported on the regenerative …

The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Epithelial organoids derived from human donor tissues are important tools in fields ranging
from regenerative medicine to drug discovery. Organoid culture requires expansion of …