In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …

Transient receptor potential (TRP) channels are not only the major contributors to Ca2+
signaling but also the targets of Ca2+ signaling. Ca2+ regulation of TRP channels involves 3 …

Hypoxia affects proliferation, differentiation, as well as death of cardiomyocyte, and plays an
important role in the development of myocardial ischemia. However, the detailed …

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial
enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance …

Ubiquitination and SUMOylation, which are posttranslational modifications, play prominent
roles in regulating both protein expression and function in cells, as well as various cellular …

Objective Retinal ischemic disease is a major cause of vision loss. Current treatment options
are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not …

The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-
arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells …