[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Updating Phospholipase A2 Biology
M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …
are subdivided into several distinct families on a structural and biochemical basis. In …
Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
K Tsuboi, T Uyama, Y Okamoto, N Ueda - Inflammation and Regeneration, 2018 - Springer
The plant Cannabis sativa contains cannabinoids represented by Δ 9-tetrahydrocannabinol,
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond
M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
Inflammation and nitro-oxidative stress as drivers of endocannabinoid system aberrations in mood disorders and schizophrenia
The endocannabinoid system (ECS) is composed of the endocannabinoid ligands
anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors …
anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors …
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
Cytosolic phospholipase A2 and lysophospholipid acyltransferases
Abstract Phospholipase A 2 (PLA 2) enzymes catalyze the hydrolysis of ester bonds at sn-2
positions of glycerophospholipids (PL), producing free fatty acids and lysophospholipids. In …
positions of glycerophospholipids (PL), producing free fatty acids and lysophospholipids. In …
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation
M Murakami, R Takamiya, Y Miki, N Sugimoto… - Biochemical …, 2022 - Elsevier
Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …
N-acylethanolamine hydrolyzing acid amidase inhibition: tools and potential therapeutic opportunities
P Bottemanne, GG Muccioli, M Alhouayek - Drug discovery today, 2018 - Elsevier
Highlights•NAAA is a key enzyme controlling the levels of bioactive N-acylethanolamines.•
Novel, systemically active inhibitors are now available to study NAAA roles in vivo.•NAAA …
Novel, systemically active inhibitors are now available to study NAAA roles in vivo.•NAAA …
The rise and fall of anandamide: processes that control synthesis, degradation, and storage
RG Biringer - Molecular and cellular biochemistry, 2021 - Springer
Anandamide is an endocannabinoid derived from arachidonic acid-containing membrane
lipids and has numerous biological functions. Its effects are primarily mediated by the …
lipids and has numerous biological functions. Its effects are primarily mediated by the …