The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant
advancement in treating neurological diseases. The BBB is a tightly packed layer of …

Natural and de novo designed peptides are gaining an ever-growing interest as drugs
against several diseases. Their use is however limited by the intrinsic low bioavailability and …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that controls the
mass transfer between blood and brain, severely limits brain penetration of systemically …

Safe and efficient medical therapy for brain diseases is still an unmet clinical need due to
various barriers represented by the blood-brain barrier. Well-designed brain targeted …

Although the blockade of immune checkpoint PD-1/PD-L1 has achieved great success, the
lack of tumor-infiltrating immune cells and PD-L1 expression in the tumor microenvironment …

As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Brain tumors are characterized by very high mortality and, despite the continuous research
on new pharmacological interventions, little therapeutic progress has been made. One of the …

Due to the special physiological and pathological characteristics of gliomas, most
therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of …