The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

In vitro transcription (IVT) is a DNA-templated process for synthesizing long RNA transcripts,
including messenger RNA (mRNA). For many research and commercial applications, IVT of …

Molecular dynamics (MD) simulations have become increasingly popular in studying the
motions and functions of biomolecules. The accuracy of the simulation, however, is highly …

We report the discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-
helical peptide to enter clinical trials. ALRN-6924 is a “stapled peptide” that mimics the N …

Understanding the relationship between amino acid sequence and protein function is a long-
standing challenge with far-reaching scientific and translational implications. State-of-the-art …

The rapid increase in drug-resistant infections has presented a serious challenge to
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …

Class B G-protein-coupled receptors (GPCRs), including glucagon-like peptide 1 receptor
(GLP1R) and parathyroid hormone 1 receptor (PTH1R), are important drug targets …

The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive
cell proliferation. A well-known target of cyclin D-Cdk4, 6 is the retinoblastoma protein Rb …

Acidic activation domains are intrinsically disordered regions of the transcription factors that
bind coactivators. The intrinsic disorder and low evolutionary conservation of activation …

HSP90 is a molecular chaperone that associates with numerous substrate proteins called
clients. It plays many important roles in human biology and medicine, but determinants of …