The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably
overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …

Vascular cognitive impairment (VCI) is the diagnostic term used to describe a
heterogeneous group of sporadic and hereditary diseases of the large and small blood …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

CADASIL and CARASIL are hereditary small vessel diseases leading to vascular dementia.
CADASIL commonly begins with migraine followed by minor strokes in mid‐adulthood …

Objective To determine the frequency of distinctive EGF r cysteine altering NOTCH 3
mutations in the 60,706 exomes of the exome aggregation consortium (Ex AC) database …

Cerebral small vessel diseases (SVDs) are a central link between stroke and dementia—two
comorbidities without specific treatments. Despite the emerging consensus that SVDs are …