Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain
U Gómez-Bouzó, C Peluso-Iltis, H Santalla… - Journal of Medicinal …, 2024 - ACS Publications
We synthesized two new gemini analogues, UG-480 and UG-481, that incorporate a
modified longer side chain containing a cyclopropane group. The evaluation of the …
modified longer side chain containing a cyclopropane group. The evaluation of the …
A vitamin D‐based strategy overcomes chemoresistance in prostate cancer
K Len‐Tayon, C Beraud, C Fauveau… - British Journal of …, 2024 - Wiley Online Library
Background and purpose Castration‐resistant prostate cancer (CRPC) is a common male
malignancy that requires new therapeutic strategies due to acquired resistance to its first …
malignancy that requires new therapeutic strategies due to acquired resistance to its first …
Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs
U Gómez-Bouzó, AY Belorusova, ML Rivadulla… - Bioorganic …, 2023 - Elsevier
Intense synthetic efforts have been directed towards the development of noncalcemic
analogs of 1, 25-dihydroxyvitamin D 3. We describe here the structural analysis and …
analogs of 1, 25-dihydroxyvitamin D 3. We describe here the structural analysis and …