Optical microscopy has been a fundamental tool of biological discovery for more than three
centuries, but its in vivo tissue imaging ability has been restricted by light scattering to …

This review describes the diffusion model for light transport in tissues and the medical
applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue …

We present a review of methods for the forward and inverse problems in optical tomography.
We limit ourselves to the highly scattering case found in applications in medical imaging …

This is a review of recent mathematical and computational advances in optical tomography.
We discuss the physical foundations of forward models for light propagation on microscopic …

A recent development in biomedical imaging is the non-invasive mapping of molecular
events in intact tissues using fluorescence. Underpinning to this development is the …

Diffuse optical tomography, also known as near infrared tomography, has been under
investigation, for non‐invasive functional imaging of tissue, specifically for the detection and …

Near-infrared spectroscopy (NIRS) and diffuse optical imaging (DOI) are finding widespread
application in the study of human brain activation, motivating further application-specific …

Diffuse optical tomography (DOT) is an ongoing medical imaging modality in which tissue is
illuminated by near-infrared light from an array of sources, the multiply-scattered light which …

State-of-the-art methods in high-resolution three-dimensional optical microscopy require that
the focus be scanned through the entire region of interest. However, an analysis of the …

Accurate and rapid detection of tumors is of great importance for interrogating the molecular
basis of cancer pathogenesis, preventing the onset of complications, and implementing a …