RNA‐based therapeutics have the potential to revolutionize the treatment and prevention of
human diseases. While early research faced setbacks, it established the basis for …

(1) Although long noncoding RNAs (lncRNAs) are known to be precursors of microRNAs
(miRNAs), they frequently act as competing endogoneous RNAs (ceRNAs), yet still their …

Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-
aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such …

The ability of fungal species to produce a wide range of enzymes and metabolites, which act
synergistically, makes them valuable tools in bioremediation, especially in the removal of …

We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs)
as microRNA and messenger RNA inhibitors. For proof of concept, we target miR-155, which …

Peptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to
natural DNA or RNA, as well as resistance to enzymatic degradation. PNA sequences can …

Glioblastoma (GBM) is an aggressive type IV brain tumor that originates from astrocytes and
has a poor prognosis. Despite intensive research, survival rates have not significantly …

In recent years, several splice switching antisense oligonucleotide (ASO)-based
therapeutics have gained significant interest, and several candidates received approval for …

Nucleobase-containing molecules are compounds essential in biology due to the
fundamental role of nucleic acids and, in particular, G-quadruplex DNA and RNA in life …

The unculturable nature of intracellular obligate symbionts presents a significant challenge
for elucidating gene functionality, necessitating the development of gene manipulation …