Characterization of RNA modifications has identified their distribution features and
molecular functions. Dynamic changes in RNA modification on various forms of RNA are …

Metazoans have developed strategies to protect themselves from pathogenic attack. These
preserved mechanisms constitute the immune system, composed of innate and adaptive …

Itaconate is produced by an enzyme encoded by the immune-responsive gene 1 (IRG1) and
exerts antibacterial, anti-inflammatory, and antioxidant effects via multiple mechanisms …

Immunometabolism contributes to inflammation, but how activated macrophages acquire
extracellular nutrients to fuel inflammation is largely unknown. Here, we show that the …

Immune sentinel macrophages initiate responses to pathogens via hundreds of immune
response genes. Each immune threat demands a tailored response, suggesting that the …

Signal integration is central to a causal understanding of appropriately scaled inflammatory
responses. Here, we discuss recent progress in our understanding of the stimulus–response …

ABSTRACT REC8 meiotic recombination protein (REC8) is a member of structural
maintenance of chromosome (SMC) protein partners, which play an important role in …

Immune system threat detection hinges on T cells' ability to perceive varying peptide–major
histocompatibility complex (pMHC) antigens. As the Erk and NFAT pathways link T cell …

Cells of the innate immune system retain memory of prior exposures through a process
known as innate immune training. β-glucan, a Dectin-1 ligand purified from the Candida …

Macrophages exposed to immune stimuli reprogram their epigenomes to alter their
subsequent functions. Exposure to bacterial lipopolysaccharide (LPS) causes widespread …