The most frequent adult-type primary CNS tumours are diffuse gliomas, but a large variety of
rarer CNS tumour types exists. The classification of these tumours is increasingly based on …

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

The mammalian brain is supplied with blood by specialized vasculature that is structurally
and functionally distinct from that of the periphery. A defining feature of this vasculature is a …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Background Primary and adaptive resistance against chemo-and radiotherapy and local
recurrence after surgery limit the benefits from these standard treatments in glioma patients …

Glioblastoma (GBM) is an aggressive primary tumor, causing thousands of deaths
worldwide every year. The mean survival of patients with GBM remains below 20 months …

In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained
prominence in several diseases of the central nervous system, especially in glioblastoma …

Cancer cells reside amongst a complex milieu of stromal cells and structural features known
as the tumor microenvironment. Often cancer cells divert and co-opt functions of stromal …

Despite significant strides made in understanding the pathophysiology of high-grade
gliomas over the past two decades, most patients succumb to these neoplasias within two …