The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …

Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for solid
tumors. However, even in cancers generally considered ICI-sensitive, responses can vary …

Background Metastasis is a major cause of death in human colorectal cancer patients.
However, the contribution of chemokines in the tumor microenvironment to tumor metastasis …

Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to
metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical …

Circular RNAs (circRNAs) are novel RNA molecules that play important roles in
chemoresistance in different cancers, including breast and gastric cancers. However …

Th17 cells are known to exert pathogenic and non-pathogenic functions. Although the
cytokine transforming growth factor β1 (TGF-β1) is instrumental for Th17 cell differentiation, it …

Simple Summary There is currently no effective treatment for patients with advanced
pancreatic ductal adenocarcinoma (PDAC). Transforming Growth Factor β (TGFβ) signaling …

There are well demonstrated differences in tumor cell metabolism between right sided
(RCC) and left sided (LCC) colon cancer, which could underlie the robust differences …