Arsenic is a trace element found in the earth, s crust at an average concentration of∼ 5 μg/g
(ppm). Although its relative abundance in the earth, s crust is about 54th, arsenic can …

Noncovalent interactions play a dominant role in many forefront areas of modern chemistry,
from materials design to molecular biology. A detailed understanding of the physical origin …

A highly stable electrochemical acetylcholinesterase (AChE) biosensor for detection of
organophosphorus pesticides (OPs) was developed simply by adsorption of AChE on …

By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates
neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme …

Cations bind to the π face of an aromatic structure through a surprisingly strong, noncovalent
force termed the cation-π interaction. The magnitude and generality of the effect have been …

A major revival in the use of classical electrostatics as an approach to the study of charged
and polar molecules in aqueous solution has been made possible through the development …

The discovery of the first neurotransmitter—acetylcholine—was soon followed by the
discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Nerve agents are organophosphorus chemical warfare agents that exert their action through
the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of …

The alpha beta-hydrolase fold family of enzymes is rapidly becoming one of the largest
group of structurally related enzymes with diverse catalytic functions. Members in this family …