Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual
dimorphism in AD is gaining attention as clinical data show that women are not only more …

Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer's …

Defects in insulin production and signaling are suspected to share a key role in diabetes
and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the …

Alzheimer's disease (AD) is clinically characterized by progressive memory loss, behavioral
and learning dysfunction and cognitive deficits, such as alterations in social interactions. The …

Transgenic mouse models of Aβ amyloidosis generated by knock-in of a humanized Aβ
sequence can offer some advantages over the transgenic models that overexpress amyloid …

Abstract Background Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of
neurological disorders, including Alzheimer's disease (AD), where MMP9 levels are …

The transferrin receptor (TfR) is highly expressed by brain capillary endothelial cells
(BCECs) forming the blood–brain barrier (BBB) and is therefore considered as a potential …

Endocrine, nervous, and immune systems work coordinately to maintain the global
homeostasis of the organism. They show sex differences in their functions that, in turn …

Alzheimer's disease (AD) has been associated with type II diabetes (T2D) and obesity in
several epidemiologic studies. To determine whether AD neuropathology can cause …