Mathematical modeling of release kinetics from supramolecular drug delivery systems

C Mircioiu, V Voicu, V Anuta, A Tudose, C Celia… - Pharmaceutics, 2019 - mdpi.com
Embedding of active substances in supramolecular systems has as the main goal to ensure
the controlled release of the active ingredients. Whatever the final architecture or entrapment …

Mathematical models as tools to predict the release kinetic of fluorescein from lyotropic colloidal liquid crystals

D Paolino, A Tudose, C Celia, L Di Marzio, F Cilurzo… - Materials, 2019 - mdpi.com
In this study, we investigated the release kinetic of fluorescein from colloidal liquid crystals
made from monoglyceride and different non-ionic surfactants. The crystals were …

Development and characterization of orally disintegrating tablets containing a captopril-cyclodextrin complex

AM Musuc, V Anuta, I Atkinson, VT Popa, I Sarbu… - Pharmaceutics, 2020 - mdpi.com
Captopril is the first angiotensin I-converting enzyme inhibitor widely used for the treatment
of hypertension. Based on the well-known benefits of cyclodextrin inclusion complexes, the …

Formulation of chewable tablets containing carbamazepine-β-cyclodextrin inclusion complex and f-melt disintegration excipient. The mathematical modeling of the …

AM Musuc, V Anuta, I Atkinson, I Sarbu, VT Popa… - Pharmaceutics, 2021 - mdpi.com
Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the
gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect …

[HTML][HTML] Exploring Deep Eutectic Solvents as Pharmaceutical Excipients: Enhancing the Solubility of Ibuprofen and Mefenamic Acid

MA Nica, V Anuța, CA Nicolae, L Popa… - …, 2024 - pmc.ncbi.nlm.nih.gov
Objectives: The study explores the potential of various deep eutectic solvents (DESs) to
serve as drug delivery systems and pharmaceutical excipients. The research focuses on two …

Biopharmaceutical profiling of new antitumor pyrazole derivatives

V Anuta, GM Nitulescu, CE Dinu-Pîrvu, OT Olaru - Molecules, 2014 - mdpi.com
Several new pyrazole derivatives have demonstrated promising antiproliferative and
cytotoxic effects, but their poor solubility raised concerns over possible biopharmaceutical …

Estimation of the In Vivo Release of Amiodarone From the Pharmacokinetics of Its Active Metabolite and Correlation With Its In Vitro Release

MR Shleghm, C Mircioiu, VA Voicu, I Mircioiu… - Frontiers in …, 2021 - frontiersin.org
Due to its very low water solubility and complex pharmacokinetics, a reliable point-to-point
correlation of its in vitro release with its pharmacokinetics has not been achieved so far with …

Effect of a new synergistic combination of low doses of acetylsalicylic acid, caffeine, acetaminophen, and chlorpheniramine in acute low back pain

VA Voicu, C Mircioiu, C Plesa, M Jinga… - Frontiers in …, 2019 - frontiersin.org
The present paper continues a more complex research related to the increased synergism in
terms of both anti-inflammatory and analgesic effect obtained by the addition of …

[PDF][PDF] Characterization of nimesulide and development of immediate release tablets

HVA Rocha, R de Sousa Augusto, LD Prado… - Eclética …, 2019 - redalyc.org
This paper aims to characterize nimesulide raw materials from different manufacturers and
to develop immediate release tablets, in order to register a generic product. Also, raw …

[PDF][PDF] Kinetic analysis of in vitro drug release from valproic acid and sodium valproate suppositories

A Ciurba, N Todoran, A Tăurean, P Antonoaea… - …, 2014 - farmaciajournal.com
The present study aims to develop new formulations of suppositories containing valproic
acid or sodium valproate for the pediatric use of anticonvulsant therapy. Seven formulations …