Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
R Pecori, S Di Giorgio, J Paulo Lorenzo… - Nature Reviews …, 2022 - nature.com
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
Carcinogenic human papillomavirus infection
Infections with human papillomavirus (HPV) are common and transmitted by direct contact.
Although the great majority of infections resolve within 2 years, 13 phylogenetically related …
Although the great majority of infections resolve within 2 years, 13 phylogenetically related …
[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
APOBEC: A molecular driver in cervical cancer pathogenesis
S Revathidevi, AK Murugan, H Nakaoka, I Inoue… - Cancer letters, 2021 - Elsevier
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …
[HTML][HTML] HPV16 E7 genetic conservation is critical to carcinogenesis
Although most cervical human papillomavirus type 16 (HPV16) infections become
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …
HPV16 and HPV18 genome structure, expression, and post-transcriptional regulation
L Yu, V Majerciak, ZM Zheng - International journal of molecular sciences, 2022 - mdpi.com
Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …
High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …
[HTML][HTML] Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution
J Ratcliff, P Simmonds - Virology, 2021 - Elsevier
Members of the APOBEC family of cytidine deaminases show antiviral activities in
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
[HTML][HTML] Evasion of host immune defenses by human papillomavirus
A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …
the absence of medical interventions. Various innate and adaptive immune responses, as …
[HTML][HTML] APOBEC3A catalyzes mutation and drives carcinogenesis in vivo
EK Law, R Levin-Klein, MC Jarvis, H Kim… - Journal of Experimental …, 2020 - rupress.org
The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second
largest source of mutation in cancer. This mutational process may be a causal driver or …
largest source of mutation in cancer. This mutational process may be a causal driver or …