Recombinant viruses are the workhorse of modern neuroscience. Whether one would like to
understand a neuron's morphology, natural activity patterns, molecular composition …

Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …

Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …

Adolescent binge drinking is a major risk factor for psychiatric disorders later in life including
alcohol use disorder. Adolescent alcohol exposure induces epigenetic reprogramming at …

Highlights•Chronic drug use alters the epigenetic state of neurons and other cell types within
brain reward regions.•Epigenetic adaptations are correlated with addiction, but their causal …

Depression is a common disorder that affects women at twice the rate of men. Here, we
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …

Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …

Repeated cocaine use induces coordinated changes in gene expression that drive plasticity
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …

Resilience enables mental elasticity in individuals when rebounding from adversity. In this
study, we identified a microcircuit and relevant molecular adaptations that play a role in …

The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …