ERBB receptors and cancer: the complexity of targeted inhibitors
NE Hynes, HA Lane - Nature Reviews Cancer, 2005 - nature.com
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
MM Moasser - Oncogene, 2007 - nature.com
The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …
Structure and function of the cell surface (tethered) mucins
CL Hattrup, SJ Gendler - Annu. Rev. Physiol., 2008 - annualreviews.org
Cell surface mucins are large transmembrane glycoproteins involved in diverse functions
ranging from shielding the airway epithelium against pathogenic infection to regulating …
ranging from shielding the airway epithelium against pathogenic infection to regulating …
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
P Nagy, E Friedländer, M Tanner, AI Kapanen… - Cancer research, 2005 - AACR
Overexpression of erbB2 in breast tumors is associated with poor prognosis and is a target
of receptor-oriented cancer therapy. Trastuzumab (Herceptin), a monoclonal antibody …
of receptor-oriented cancer therapy. Trastuzumab (Herceptin), a monoclonal antibody …
The neuregulin-I/ErbB signaling system in development and disease
S Britsch - 2007 - books.google.com
Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase
receptors of the ErbB family. Neuregulin signals are also involved in the development …
receptors of the ErbB family. Neuregulin signals are also involved in the development …
[HTML][HTML] Structure, evolution, and biology of the MUC4 mucin
Mucins are high-molecular-weight glycoproteins and are implicated in diverse biological
functions. MUC4, a member of transmembrane mucin family, is expressed in airway …
functions. MUC4, a member of transmembrane mucin family, is expressed in airway …
Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis
The MUC4 mucin is a high molecular weight membrane-bound glycoprotein. It is aberrantly
expressed in pancreatic tumors and tumor cell lines with no detectable expression in the …
expressed in pancreatic tumors and tumor cell lines with no detectable expression in the …
A review of HER2 overexpression and somatic mutations in cancers
M Galogre, D Rodin, M Pyatnitskiy… - Critical Reviews in …, 2023 - Elsevier
Abstract The Human Epidermal Growth Factor Receptor (HER) proteins family, which
includes HER2, are membrane-bound receptors that activate many intracellular pathways …
includes HER2, are membrane-bound receptors that activate many intracellular pathways …
Mucin expression profile in pancreatic cancer and the precursor lesions
K Nagata, M Horinouchi, M Saitou… - Journal of Hepato …, 2007 - Wiley Online Library
In this review article, we demonstrate the mucin expression profile in normal tissue, invasive
ductal carcinoma (IDC), two subtypes of intraductal papillary—mucinous neoplasm (IPMN …
ductal carcinoma (IDC), two subtypes of intraductal papillary—mucinous neoplasm (IPMN …
Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer
Understanding the molecular mechanisms involved in tumorigenesis and their influence on
clinical outcome is providing specific molecular markers for targeted therapy. Activation of …
clinical outcome is providing specific molecular markers for targeted therapy. Activation of …