Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological
and clinical features. The biologic basis of the stereotypical progression from chronic phase …

Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

Hematopoiesis is a process capable of generating millions of cells every second, as
distributed in many cell types. The process is regulated by a number of transcription factors …

The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia
chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen …

Abstract Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the
catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better …

The Wnt signaling pathway is essential in the development and homeostasis of blood and
immune cells, but its exact role is still controversial and is the subject of intense research …

In this study, we provide a molecular signature of highly enriched CD34+ cells from bone
marrow of untreated patients with chronic myelogenous leukemia (CML) in chronic phase in …

Chronic myeloid leukemia (CML) has long served as a paradigm for generating new insights
into the cellular origin, pathogenesis and improved approaches to treating many types of …