DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Neurons are exposed to high levels of DNA damage from both physiological and
pathological sources. Neurons are post-mitotic and their loss cannot be easily recovered …

DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates
with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells …

Although, the nucleolus has been observed for almost 200 years in neurons, studies that
directly address the neuronal roles of this subnuclear structure have appeared only recently …

Cellular senescence is a major driver of age-related diseases, and senotherapies are being
tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is …

Head and neck cancer (HNC) is the sixth most common human malignancy with a global
incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective …

Although axonal damage induces rapid changes in gene expression in primary sensory
neurons, it remains unclear how this process is initiated. The transcription factor ATF3, one …

Chemotherapy-induced intestinal mucositis (CIM) is a common adverse reaction to
antineoplastic treatment with few appropriate, specific interventions. We aimed to identify the …