Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

Papers and patents that deal with polymorphism (crystal systems for which a substance can
exist in structures defined by different unit cells and where each of the forms has the same …

Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble
drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are …

Despite their widespread use for purification, our current methods for the development of
solution crystallization processes lack a sufficient understanding on how impurities …

Pharmaceutical cocrystals and salts are extensively researched in recent years due to their
ability to tune the physicochemical properties of active pharmaceutical ingredients (APIs). A …

An extensive experimental search for solid forms of the antipsychotic compound olanzapine
identified 60 distinct solid forms including three nonsolvated polymorphs, 56 crystalline …

We show how dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy
can be used to characterize polymorphs and solvates of organic solids. We applied DNP to …

A novel cocrystallization form of amantadine hydrochloride (AMNH) with sulfathiazole (SUZ),
as the first example of dual-drug cocrystal simultaneously containing antiviral drug and …