Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …

Heart failure affects≈ 5.7 million people in the United States alone. Angiotensin-converting
enzyme inhibitors, angiotensin receptor blockers, β-blockers, and aldosterone antagonists …

Angioedema is an acute swelling of the deeper layers of the skin or mucosa resulting from a
transient increase in vascular permeability. Angioedema can occur in the absence or …

Abstract Purpose of Review This study aims to examine current knowledge on the
occurrence, pathophysiology, and treatment of angioedema among patients who receive …

Bradykinin (BK) metabolism and its receptors play a central role in drug-induced
angioedema (AE) without urticaria through increased vascular permeability. Many …

Contemporary genetic research has provided evidences that angioedema represents a
diverse family of disorders related to kinin metabolism, with a much greater genetic …

Angioedema (AE) occurring during ACE inhibitor therapy (ACEi-AE) is a rare complication
involving between 0.1 and 0.7% of treated patients. AE can also complicate other …

Bradykinin has important physiological actions related to the regulation of blood vessel tone
and renal function, and protection from ischemia reperfusion injury. However, bradykinin …

Although chronic spontaneous urticaria (CSU) is a common disease, GWASs of CSU are
lacking. We aimed to identify susceptibility SNPs by performing a GWAS in Chinese Han …

Off‐target adverse drug reactions (ADRs) are associated with significant morbidity and costs
to the healthcare system, and their occurrence is not predictable based on the known …