Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …

Known protein coding gene exons compose less than 3% of the human genome. The
remaining 97% is largely uncharted territory, with only a small fraction characterized. The …

Background Long noncoding RNAs (lncRNAs) are a recently discovered class of non-
protein coding RNAs, which have now increasingly been shown to be involved in a wide …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has
become the main method of early screening for lung cancer due to the low sensitivity of …

DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …