Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

Disulfides in peptides and proteins are essential for maintaining a properly folded structure.
Their oxidative folding is invariably performed in an aqueous‐buffered solution. However …

Covering 1965 to February 2024Plants are prolific peptide chemists and are known to make
thousands of different peptidic molecules. These peptides vary dramatically in their size …

Hevein-like antimicrobial peptides (AMPs) comprise a family of plant AMPs with antifungal
activity, which harbor a chitin-binding site involved in interactions with chitin of fungal cell …

Chitin-binding hevein-like peptides (CB-HLPs) belong to a family of cysteine-rich peptides
that play important roles in plant stress and defense mechanisms. CB-HLPs are ribosomally …

In recent decades, bioactive peptides have been gaining recognition in various biomedical
areas, such as intracellular drug delivery (cell-penetrating peptides, CPPs) or anti-infective …

Heveins and hevein-containing (hev-) lectins play important roles in stress and pathogenic
responses in plants but cause health concerns in humans. Hev-hololectins contain multiple …

Here, we report the discovery of the first plant-derived and noncanonical epidermal growth
factor receptor (EGFR) agonist, the 36-residue bleogen pB1 from Pereskia bleo of the …

Corneal scarring reduces corneal transparency, compromises vision, and is a major cause
of vision loss worldwide. Epidermal growth factor (EGF), which is the prototypic member of …