Aromatic compounds containing triazenyl groups (N3RR′) have a profound impact on
synthetic organic and medicinal chemistry. In contrast, the chemistry of vinyl and alkynyl …

Majority of the representative drugs customarily interact with multiple targets manifesting
unintended side effects. In addition, drug resistance and over expression of the cellular …

Benzyne and related arynes are classical high‐energy species with a rich history of
widespread applications in synthesis. However, despite several synthetic routes being …

Fluorinated pyridones are an important scaffold displaying relevant biological activities.
Efficient assembly strategies of pyridones are transition metal-catalyzed C–H annulations …

A novel series of cis-diphenylethene and benzophenone derivatives as tubulin/HDAC dual-
targeting inhibitors were designed and synthesized. Among them, compound 28g exhibited …

The aggressiveness of melanoma and lack of effective therapies incite the discovery of
novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene …

Melanoma is the most aggressive form of skin cancer, with increasing incidence and
mortality rates. To overcome current treatment limitations, a hybrid molecule (HM) combining …

A series of compounds incorporating 3-(3-(2/3/4-substituted phenyl) triaz-1-en-1-yl)
benzenesulfonamide moieties were synthesised and their chemical structure was confirmed …

Simultaneous inhibition of more than one target is considered to be a novel strategy in
cancer therapy. Owing to the importance of histone deacetylases (HDACs) and p53-murine …

The synthetic utility of triazenes rests on the fact that the triazene function can be cleaved by
Brønsted or Lewis acids, liberating diazonium compounds. However, the preferred …