[HTML][HTML] Role of androgen receptor in prostate cancer: a review
K Fujita, N Nonomura - The world journal of men's health, 2019 - synapse.koreamed.org
Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
PA Watson, VK Arora, CL Sawyers - Nature Reviews Cancer, 2015 - nature.com
During the past 10 years, preclinical studies implicating sustained androgen receptor (AR)
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …
Androgen receptor: structure, role in prostate cancer and drug discovery
Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …
The regulation of spermatogenesis by androgens
Testosterone is essential for maintaining spermatogenesis and male fertility. However, the
molecular mechanisms by which testosterone acts have not begun to be revealed until …
molecular mechanisms by which testosterone acts have not begun to be revealed until …
Androgen receptor function and targeted therapeutics across breast cancer subtypes
EA Kolyvas, C Caldas, K Kelly, SS Ahmad - Breast Cancer Research, 2022 - Springer
Despite significant progress in breast cancer (BC) therapy, it is globally the most commonly
diagnosed cancer and leads to the death of over 650,000 women annually. Androgen …
diagnosed cancer and leads to the death of over 650,000 women annually. Androgen …
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
K Hoffmeyer, A Raggioli, S Rudloff, R Anton… - Science, 2012 - science.org
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging,
and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the …
and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the …
Androgen receptor in prostate cancer
CA Heinlein, C Chang - Endocrine reviews, 2004 - academic.oup.com
The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …
through the androgen receptor (AR). AR remains important in the development and …
Molecular determinants of resistance to antiandrogen therapy
CD Chen, DS Welsbie, C Tran, SH Baek, R Chen… - Nature medicine, 2004 - nature.com
Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …
that a modest increase in androgen receptor mRNA was the only change consistently …
Development of selective androgen receptor modulators (SARMs)
Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
R Hu, TA Dunn, S Wei, S Isharwal, RW Veltri… - Cancer research, 2009 - AACR
Suppression of androgen production and function provides palliation but not cure in men
with prostate cancer (PCa). Therapeutic failure and progression to hormone-refractory PCa …
with prostate cancer (PCa). Therapeutic failure and progression to hormone-refractory PCa …