Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …

During the past 10 years, preclinical studies implicating sustained androgen receptor (AR)
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …

Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Testosterone is essential for maintaining spermatogenesis and male fertility. However, the
molecular mechanisms by which testosterone acts have not begun to be revealed until …

Despite significant progress in breast cancer (BC) therapy, it is globally the most commonly
diagnosed cancer and leads to the death of over 650,000 women annually. Androgen …

Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging,
and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

Suppression of androgen production and function provides palliation but not cure in men
with prostate cancer (PCa). Therapeutic failure and progression to hormone-refractory PCa …