Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies
A Nogueira, MJ Pires, PA Oliveira - In vivo, 2017 - iv.iiarjournals.org
Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work
correctly. It has a high prevalence and represents a serious hazard to human health and …
correctly. It has a high prevalence and represents a serious hazard to human health and …
Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects
FJ López-Hernández, JM López-Novoa - Cell and tissue research, 2012 - Springer
Transforming growth factor beta (TGF-β) has been recognized as an important mediator in
the genesis of chronic kidney diseases (CKD), which are characterized by the accumulation …
the genesis of chronic kidney diseases (CKD), which are characterized by the accumulation …
Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial
S Gullaksen, L Vernstrøm, SS Sørensen, S Ringgaard… - Diabetologia, 2023 - Springer
Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1ras) and sodium–glucose
cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects. Improved kidney …
cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects. Improved kidney …
Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications
JM López-Novoa, AB Rodríguez-Peña, A Ortiz… - Journal of translational …, 2011 - Springer
Chronic kidney disease (CKD) comprises a group of pathologies in which the renal
excretory function is chronically compromised. Most, but not all, forms of CKD are …
excretory function is chronically compromised. Most, but not all, forms of CKD are …
Obstructive sleep apnea and kidney disease: a potential bidirectional relationship?
Chronic kidney disease (CKD) is associated with high mortality rates and heavy economic
and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal …
and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal …
An in-silico identification of potential flavonoids against kidney fibrosis targeting TGFβR-1
Fibrosis is a hallmark of progressive kidney diseases. The overexpression of profibrotic
cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and …
cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and …
Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor
RM Hazem, SA Antar, YK Nafea, AA Al-Karmalawy… - Life Sciences, 2022 - Elsevier
Aims Doxorubicin is a prominent anticancer agent. However, its organotoxic potential has
restricted its clinical use. The current study was performed to investigate the protective effect …
restricted its clinical use. The current study was performed to investigate the protective effect …
Extracellular vesicles in organ fibrosis: mechanisms, therapies, and diagnostics
DR Brigstock - Cells, 2021 - mdpi.com
Fibrosis is the unrelenting deposition of excessively large amounts of insoluble interstitial
collagen due to profound matrigenic activities of wound-associated myofibroblasts during …
collagen due to profound matrigenic activities of wound-associated myofibroblasts during …
Recent advances of CREKA peptide-based nanoplatforms in biomedical applications
N Zhang, B Ru, J Hu, L Xu, Q Wan, W Liu… - Journal of …, 2023 - Springer
Nanomedicine technology is a rapidly developing field of research and application that uses
nanoparticles as a platform to facilitate the diagnosis and treatment of diseases …
nanoparticles as a platform to facilitate the diagnosis and treatment of diseases …
Association of remnant cholesterol with chronic kidney disease in middle-aged and elderly Chinese: a population-based study
P Yan, Y Xu, Y Miao, X Bai, Y Wu, Q Tang, Z Zhang… - Acta Diabetologica, 2021 - Springer
Aims Limited data regarding the association between remnant cholesterol (RC) and chronic
kidney disease (CKD), largely based on an estimated glomerular filtration rate (eGFR) of< …
kidney disease (CKD), largely based on an estimated glomerular filtration rate (eGFR) of< …