[HTML][HTML] Paraoxonase-1 as a regulator of glucose and lipid homeostasis: impact on the onset and progression of metabolic disorders

MJ Meneses, R Silvestre, I Sousa-Lima… - International journal of …, 2019 - mdpi.com
Metabolic disorders are characterized by an overall state of inflammation and oxidative
stress, which highlight the importance of a functional antioxidant system and normal activity …

HDL functionality in type 1 diabetes

S Ganjali, GM Dallinga-Thie, LE Simental-Mendía… - Atherosclerosis, 2017 - Elsevier
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by absence
of insulin secretion due to destruction of the pancreatic beta-cells. Patients with T1D exhibit …

[HTML][HTML] Endothelial dysfunction in diabetes is aggravated by glycated lipoproteins; novel molecular therapies

L Toma, CS Stancu, AV Sima - Biomedicines, 2020 - mdpi.com
Diabetes and its vascular complications affect an increasing number of people. This disease
of epidemic proportion nowadays involves abnormalities of large and small blood vessels …

[HTML][HTML] Dietary strategies to improve cardiovascular health: focus on increasing high-density lipoprotein functionality

JT Stadler, G Marsche - Frontiers in Nutrition, 2021 - frontiersin.org
Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide,
with increasing incidence. A cornerstone of cardiovascular disease prevention is lifestyle …

Effect of advanced glycation end product on paraoxonase 2 expression: Its impact on endoplasmic reticulum stress and inflammation in HUVECs

R Ravi, NR Nagaraj, BS Rajesh - Life sciences, 2020 - Elsevier
Background Paraoxonase (PON), an antioxidant enzyme, comprises of three members
(PON1, 2 and 3). Hyperglycemia accelerates formation of AGE in diabetes which mediates …

Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation

ST Chiesa, M Charakida, E McLoughlin… - European Heart …, 2019 - academic.oup.com
Aims High-density lipoprotein (HDL) function may be altered in patients with chronic
disease, transforming the particle from a beneficial vasoprotective molecule to a noxious pro …

Punicalagin decreases serum glucose levels and increases PON1 activity and HDL anti‐inflammatory values in Balb/c mice fed a high‐fat diet

D Atrahimovich, AO Samson, A Khattib… - Oxidative Medicine …, 2018 - Wiley Online Library
Polyphenols are consumed daily in the human diet and are associated with reduced risk of a
number of chronic diseases, including cancer, cardiovascular disease, and diabetes …

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

D Wu, C Wu, Y Zhong - Journal of Cellular and Molecular …, 2018 - Wiley Online Library
We carried out this meta‐analysis to explore the influence of paraoxonase 1 activity on the
susceptibility of diabetes mellitus (DM), diabetic macroangiopathy and diabetic …

[HTML][HTML] Evaluation of paraoxonase, arylesterase, and homocysteine thiolactonase activities in patients with diabetes and incipient diabetes nephropathy

D Ayan, M Şeneş, AB Çaycı, S Söylemez… - Journal of medical …, 2019 - ncbi.nlm.nih.gov
Background The aim of this study is to examine the relationship among the changes in
activities of paraoxonase (PON), arylesterase (ARE) and homocysteine thiolactonase …

Lyso‐DGTS lipid isolated from microalgae enhances PON1 activities in vitro and in vivo, increases PON1 penetration into macrophages and decreases cellular lipid …

L Dahli, D Atrahimovich, J Vaya, S Khatib - BioFactors, 2018 - Wiley Online Library
High‐density lipoprotein (HDL) plays an important role in preventing atherosclerosis. The
antioxidant effect of HDL is mostly associated with paraoxonase 1 (PON1) activity …