From 2D to 3D cancer cell models—the enigmas of drug delivery research
Over the past decades, research has made impressive breakthroughs towards drug delivery
systems, resulting in a wide range of multifunctional engineered nanoparticles with …
systems, resulting in a wide range of multifunctional engineered nanoparticles with …
Proteinaceous hydrogels for bioengineering advanced 3D tumor models
The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …
[HTML][HTML] Animal-derived products in science and current alternatives
AC Duarte, EC Costa, HAL Filipe, SM Saraiva… - Biomaterials …, 2023 - Elsevier
More than fifty years after the 3Rs definition and despite the continuous implementation of
regulatory measures, animals continue to be widely used in basic research. Their use …
regulatory measures, animals continue to be widely used in basic research. Their use …
Integrated cancer tissue engineering models for precision medicine
Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …
highly organized and interconnected organ systems. Tumor cells reside in complex …
Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics
A Crabbe, L Ostyn, S Staelens, C Rigauts… - PLoS …, 2019 - journals.plos.org
Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that
do not consider the complex host microenvironment. This may help explaining a significant …
do not consider the complex host microenvironment. This may help explaining a significant …
Influences of the 3D microenvironment on cancer cell behaviour and treatment responsiveness: A recent update on lung, breast and prostate cancer models
LS Costard, RR Hosn, H Ramanayake, FJ O'Brien… - Acta Biomaterialia, 2021 - Elsevier
The majority of in vitro studies assessing cancer treatments are performed in two-
dimensional (2D) monolayers and are subsequently validated in in vivo animal models …
dimensional (2D) monolayers and are subsequently validated in in vivo animal models …
[HTML][HTML] Graphene inks for the 3D printing of cell culture scaffolds and related molecular arrays
Abstract 3D printing technology has changed academia and industry perception regarding
the course of evolution in the manufacturing of customizable products, paving the way …
the course of evolution in the manufacturing of customizable products, paving the way …
Recent progress in 3d printing of 2d material‐based macrostructures
Abstract 2D materials have a range of unique properties and are promising building blocks
for the fabrication of macroscopic materials for many applications ranging from flexible …
for the fabrication of macroscopic materials for many applications ranging from flexible …
Advances in 3D peptide hydrogel models in cancer research
In vitro cell culture models on monolayer surfaces (2D) have been widely adapted for
identification of chemopreventive food compounds and food safety evaluation. However, the …
identification of chemopreventive food compounds and food safety evaluation. However, the …
Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts
In many solid tumours a desmoplastic reaction takes place, which results in tumour tissue
stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as …
stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as …