It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

Insulin undergoes agglomeration with (subtle) changes in its biochemical environment,
including acidity, application of heat, ionic imbalance, and exposure to hydrophobic …

Insulin replacement therapy is essential for the management of diabetes. However, despite
the relative success of this therapeutic strategy, there is still a need to improve glycaemic …

Protein microenvironment is critical to study protein function and stability, which crucially
depend on their interaction with co-solvents. In the current study, the ability of synthesized …

Phenol-soluble modulins (PSMs) are extracellular short amphipathic peptides secreted by
the bacteria Staphylococcus aureus (S. aureus). They play an essential role in the bacterial …

Aims and objectives The aim of this study is to discuss the influence of endotoxin on insulin
amyloid formation, to provide guidance for therapeutic insulin preparation and storage …

The detachable dissolving microneedles (DDMNs) feature an array of needles capable of
being separated from the base sheet during administration. Here they were fabricated to …

Atrial fibrillation (AF) is a comorbidity of a variety of other chronic, inflammatory diseases for
which fibrinaloid microclots are a known accompaniment (and in some cases, a cause, with …

Iatrogenic amyloidosis results from medical therapeutic interventions, leading to the
misfolding and aggregation of proteins into amyloid fibrils or to their direct deposition in …