Therapeutic cloning, whereby somatic cell nuclear transfer (SCNT) is used to generate
patient-specific embryonic stem cells (ESCs) from blastocysts cloned by nuclear transfer …

Assisted reproductive techniques developed for cattle in the last 25 years, like ovum pick up
(OPU), intracytoplasmic sperm injection (ICSI), and somatic cell nuclear transfer, have been …

Background During mammalian pre-implantation embryonic development dramatic and
orchestrated changes occur in gene transcription. The identification of the complete changes …

Implantation is crucial for placental development that will subsequently impact fetal growth
and pregnancy success with consequences on postnatal health. We postulated that the …

The birth of 'Dolly', the first mammal cloned from an adult donor cell, has sparked a flurry of
research activities to improve cloning technology and to understand the underlying …

The birth of “Dolly,” the first mammal cloned from an adult mammary epithelial cell,
abolished the decades-old scientific dogma implying that a terminally differentiated cell …

Global activation of the embryonic genome is the most critical event in early mammalian
development. After fertilization, a rich supply of maternal proteins and RNAs support …

It is now over a decade since the birth, in 1996, of Dolly the first animal to be produced by
nuclear transfer using an adult derived somatic cell as nuclear donor. Since this time similar …

Reproductive cloning is uniformly rejected as a valid technology in humans because of the
severely abnormal phenotypes seen in cloned animals. Gene expression aberrations …

Prior to follicle selection into the preovulatory hierarchy, hen granulosa cells from
prehierarchal follicles remain undifferentiated, as defined in part by the virtual absence of …