Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Abstract The amyloid-β1–42 (Aβ42) peptide rapidly aggregates to form oligomers, protofibils
and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's …

▪ Abstract Many neurodegenerative diseases, including Alzheimer's and Parkinson's and the
transmissible spongiform encephalopathies (prion diseases), are characterized at autopsy …

Several pathogenic Alzheimer's disease (AD) mutations have been described, all of which
cause increased amyloid β-protein (Aβ) levels. Here we present studies of a pathogenic …

Alzheimer's disease affects millions of people around the world. Currently, there are no
treatments that prevent or slow the disease. Like other neurodegenerative diseases …

Objectives Amyloid‐β42 (Aβ42) appears central to Alzheimer's disease (AD) pathogenesis
and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Aβ42 is …

Background Alzheimer disease (AD) may be caused by the toxic accumulation of β-amyloid
(Aβ). Objective To test this theory, we developed a clinical intervention using clioquinol, a …