Beckwith-Wiedemann syndrome (BWS), a human genomic imprinting disorder, is
characterized by phenotypic variability that might include overgrowth, macroglossia …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Beckwith–Wiedemann syndrome (BWS) is a model disorder for the study of imprinting,
growth dysregulation, and tumorigenesis. Unique observations in this disorder point to an …

Beckwith-Wiedemann syndrome (BWS) is a human genomic imprinting disorder that
presents with a wide spectrum of clinical features including overgrowth, abdominal wall …

BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …

BACKGROUND Increasing numbers of children are being conceived by assisted
reproductive technology (ART). A number of studies have highlighted an altered epigenetic …

Mammalian preimplantation development, which is the period extending from fertilization to
implantation, results in the formation of a blastocyst with three distinct cell lineages. Only one …

Epigenetic modifications characterized by DNA methylation, histone modifications, and
chromatin remodeling are important regulators in a number of biological processes …

Epidemiological data indicate that children conceived in vitro have a greater relative risk of
low birth-weight, major and minor birth defects, and rare disorders involving imprinted …

Beckwith–Wiedemann syndrome (BWS) is an imprinting disorder characterized by
overgrowth, tumor predisposition, and congenital malformations. Approximately 85% of …