Despite rapid advances in modern medical technology and significant improvements in
survival rates of many cancers, pancreatic cancer is still a highly lethal gastrointestinal …

Currently, there are no effective preventive strategies for pancreatic cancer. Obesity has
been increasingly recognized as a strong but modifiable risk factor of pancreatic cancer. In …

The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are
complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but …

Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the
underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in …

Abstract Lipocalin-2 (LCN2) promotes malignant development in many cancer types. LCN2
is upregulated in patients with pancreatic ductal adenocarcinoma (PDAC) and in obese …

There is compelling epidemiological evidence linking obesity to many tumours; however, the
molecular mechanisms fuelling this association are not clearly understood. Emerging …

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The
worldwide estimates of its incidence and mortality in the general population are eight cases …

Pancreatic cancer is one of the leading determinants of global cancer mortality, and its
incidence is predicted to increase, to become in 2030 the second most common cause of …

Simple Summary Obesity is recognized as a chronic progressive disease and risk factor for
many human diseases. The high and increasing number of obese people may underlie the …

As one of the most fatal gastrointestinal cancers, pancreatic cancer (PC) has a long-term
survival rate that has shown limited improvement during recent decades and remains …