Noncovalent interactions are essential for the existence of solid and liquid phases. 1, 2
Traditionally touted as weak forces, quantification of these interactions, which govern the …

This article reviews the production of different phenotypes from the same genotype in the
same environment by stochastic cellular events, nonlinear mechanisms during patterning …

Abstract N 6-methyladenosine (m6A) is the most abundant internal modification of nearly all
eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain …

The multidomain CCCTC-binding factor (CTCF), containing a tandem array of 11 zinc
fingers (ZFs), modulates the three-dimensional organization of chromatin. We crystallized …

Many anecdotal observations exist of a regulatory effect of DNA methylation on gene
expression. However, in general, the underlying mechanisms of this effect are poorly …

In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

DNA structure functions as an overlapping code to the DNA sequence. Rapid progress in
understanding the role of DNA structure in gene regulation, DNA damage recognition and …

Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1: 5000 boys.
The severity of the phenotype varies dependent on the mutation site in the DMD gene and …

Demethylation of 5-methylcytosine in DNA is integral to the maintenance of an intact
epigenome. The balance between the presence or absence of 5-methylcytosine determines …

DNA methylation is a prevalent epigenetic modification involved in regulating a number of
essential cellular processes, including genomic accessibility and transcriptional outcomes …